Research and Publications
1. Quality Risk Management in the Final Operational Stage of Sterile Pharmaceutical Manufacturing: A Case Study Highlighting the Management of Sustainable Related Risks in Product Sterilization, Inspection, Labeling, Packaging, and Storage Processes. Bassam Elmadhoun, Rawidh Alsaidalani, Frank Burczynski. Sustainability 2025, 17(4), 1670; hrrps:// doi.org/10.3390/su17041670
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2. Quality Risk Management in Pharmaceutical Manufacturing Operations: Case Study for Sterile Product Filling and Final Product Handling Stage. R Alsaidalani, B Elmadhoun - Sustainability 2022, 14(15), 9618
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3. Quality Risk Management in Pharmaceutical Supply Chain, Warehousing and Dispensing-Practical Case Study from Sterile Pharmaceutical Industry. R Alsaidalani, B Elmadhoun - Int. J. Pharm. Sci. Rev. Res., 68(2), May - June 2021; Article No. 23, Pages: 155-164
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4. Fluorescent Fatty Acid Transfer from Bovine Serum Albumin to Phospholipid Vesicles: Collision or Diffusion Mediated Uptake. B. M. Elmadhoun, Manal A. Swairjo, and Frank J. Burczynski. J. Pharm PharmSci, 15 (3): 420-432, 2012
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5. “Assessing the Cellular Transmembrane Electrical Potential Difference on the Hepatic Uptake of Palmitate” F.J. Burczynski, B. Elmadhoun, G.Q. Wang, A. Lewis, P. Chang, D. Hung, M.S. Roberts. , Molecular and Cellular Biochemistry 270:115-124, 2005
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6. Hepatic Uptake of Protein-Bound palmitate: Role of Extracellular Binding proteins. Bassam Elmadhoun, 2001, University of Manitoba, Winnipeg, Manitoba, Canada
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7. “Hepatocyte [3H]-palmitate Uptake: Effect of Albumin Surface Charge Modification” Burczynski, F.J., G.-Q. Wang, B.M. Elmadhoun, Y.M. She, and K.G. Standing. Can. J. Physiol. Pharmacol. 79(10): 868-875, 2001
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8. “Palmitate Uptake by Neonatal Rat Myocytes and Hepatocytes: Role of Extracellular Protein” Elmadhoun, B.M, Lorrie A. Krishenbaum, and Frank J. Burczynski. Eur. J. Biochem., 268(11): 3145-3153, 2001
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9. “Binding of [3H] palmitate to Bovine Serum Albumin” Elmadhoun, B.M, G.Q. Wang, J.F. Templeton, and F.J. Burczynski. Am. J. Physiol., 275: G638-G644, 1998
Scientific Research Overview
1. Our research work at faculty of Pharmacy, University of Manitoba, Canada focuses on the cellular drug uptake mechanisms in adult and neonatal hepatocytes and cardiac myocytes. We are investigating the uptake process of lipophilic substrates such as long-chain fatty acids and the influence of extracellular and intracellular binding proteins on this process. Experimental studies are based on mathematical models of the uptake process. More details could be submitted upon request.
2. Our current research interest is developing a technique to improve therapeutic objectives of medicines such as maximizing drug effect and minimizing drug adverse reactions. The current research trend and technology focuses on using drug delivery system (DDS). Recent research shows that by designing and optimizing DDS such as polymer – based nanoparticles, we can enhance the pharmacological and therapeutic properties of various parenterally administered drugs. Now days, many of the problems seen in such system have been overcome. In addition, there is interest in exploring the advantages of DDS in genomic research.