Research and Publications
1. Our research work at faculty of Pharmacy, University of Manitoba, Canada focuses on the cellular drug uptake mechanisms in adult and neonatal hepatocytes and cardiac myocytes. We are investigating the uptake process of lipophilic substrates such as long-chain fatty acids and the influence of extracellular and intracellular binding proteins on this process. Experimental studies are based on mathematical models of the uptake process. More details could be submitted upon request.
2. Our current research interest is developing a technique to improve therapeutic objectives of medicines such as maximizing drug effect and minimizing drug adverse reactions. The current research trend and technology focuses on using drug delivery system (DDS). Recent research shows that by designing and optimizing DDS such as polymer – based nanoparticles, we can enhance the pharmacological and therapeutic properties of various parenterally administered drugs. Now days, many of the problems seen in such system have been overcome. In addition, there is interest in exploring the advantages of DDS in genomic research.
1. Abstract with the title “Binding of [3H] palmitate to Bovine Serum Albumin “. B.M. Elmadhoun, G.Q. Wang, and F.J. Burczynski. Submitted to the American Association for the Study of Liver Diseases, Chicago, Illinois, November 1997 and published in the supplement to the October 1997 issue of Hepatology
2. “Binding of [3H] palmitate to Bovine Serum Albumin” Elmadhoun, B.M., G.Q. Wang, J.F. Templeton, and F.J. Burczynski. Am. J. Physiol., 275: G638-G644, 1998.
3. “Palmitate Uptake by Neonatal Rat Myocytes and Hepatocytes: Role of Extracellular Protein” Elmadhoun, B.M.,Lorrie A.. Krishenbaum, and Frank J. Burczynski. Eur. J. Biochem., 268(11): 3145-3153, 2001.
4. “Hepatocyte [3H]-palmitate Uptake: Effect of Albumin Surface Charge Modification” Burczynski, F.J., G.-Q. Wang, B.M. Elmadhoun., Y.M. She, and K.. G. Standing. Can. J. Physiol. Pharmacol. 79(10): 868-875, 2001.
5. Theses title, Hepatic Uptake of Protein-Bound palmitate: Role of Extracellular Binding proteins. Bassam Elmadhoun, 2001, University of Manitoba, Winnipeg, Manitoba, Canada.
6. “Assessing the Cellular Transmembrane Electrical Potential Difference on the Hepatic Uptake of Palmitate” F.J. Burczynski, B. Elmadhoun, G.Q. Wang, A. Lewis, P. Chang, D. Hung, M.S. Roberts. , Molecular and Cellular Biochemistry 270:115-124, 2005.
7. Fluorescent Fatty Acid Transfer from Bovine Serum Albumin to Phospholipid Vesicles: Collision or Diffusion Mediated Uptake. B. M. Elmadhoun, Manal A. Swairjo, and Frank J. Burczynski. J. Pharm Pharm Sci, 15 (3): 420-432, 2012.